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Vitamin D Deficiency and Fibromyalgia: Addressing Chronic Pain and Fatigue through Serum Level Assessment

Middle-aged Hispanic woman sitting in an armchair with a contemplative and hopeful expression in a room illuminated by natural light. Next to her, a table with a glass of water and a bottle of vitamin D supplements, highlighting the theme of vitamin D deficiency and its connection to chronic musculoskeletal pain and fatigue. In the background, a bookshelf filled with medical books and plants, creating a warm and knowledgeable atmosphere.

Fibromyalgia is a chronic syndrome characterized by generalized musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms. Despite advances in understanding its pathophysiology, treatment remains a challenge. In this context, vitamin D deficiency has emerged as a potential contributing factor, given its role in pain modulation and inflammation.

Exploring the Relationship Between Vitamin D and Fibromyalgia

Research has shown that vitamin D deficiency is common in patients with chronic pain, including those with fibromyalgia. However, the results regarding the efficacy of vitamin D supplementation in improving fibromyalgia symptoms have been mixed. A recent study suggests that supplementation may be beneficial in individuals with low serum levels of vitamin D, although no significant association was observed with fibromyalgia in general.

Another study highlights that low vitamin D levels may be related to increased central pain sensitivity, which could explain the exacerbation of symptoms in patients with fibromyalgia. However, the relationship between vitamin D deficiency and generalized pain index was not significant, suggesting that vitamin D may influence pain perception more than its distribution.

Additionally, a study found a negative correlation between vitamin D levels and the impact of fibromyalgia, indicating that lower concentrations of vitamin D could be associated with a greater impact of the disease. This suggests that serum level assessment of vitamin D could be a useful tool in the management of fibromyalgia.

Conclusions

Current evidence suggests that vitamin D deficiency is prevalent in patients with fibromyalgia and may contribute to the severity of symptoms. Although vitamin D supplementation has shown potential benefits in some studies, further research is needed to establish clear recommendations. Serum level assessment of vitamin D should be considered in the comprehensive management of fibromyalgia, especially in patients with persistent musculoskeletal pain and fatigue.

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Created 6/1/2025