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Psoriasis Treatment: Topical, Systemic, and Biological Therapies Including Methotrexate and TNF Inhibitors

A middle-aged Hispanic woman sits relaxed on an examination table in a modern medical consultation room. A Hispanic doctor in his 40s shows her a diagram of the skin layers on a tablet. In the background, there are topical creams, pill bottles, and a box labeled 'biologics,' highlighting a collaborative approach to psoriasis treatment, including options like phototherapy, methotrexate, and TNF inhibitors for effective skin care.

Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. Its management requires a multidisciplinary approach that encompasses everything from topical therapies to systemic and biological treatments. In this article, we will explore the available therapeutic options, their mechanisms of action, and emerging trends in psoriasis treatment.

Diving Deeper into Psoriasis Treatment

The treatment of psoriasis is tailored to the severity of the disease and the individual characteristics of the patient. For mild to moderate cases, topical therapies are the first line of treatment. These include corticosteroids, vitamin D analogs, and combinations of both, which have proven effective and safe for the initial management of the disease [1].

In more severe cases, systemic therapies such as methotrexate, cyclosporine, and oral retinoids are employed. These treatments are effective but require careful monitoring due to their potential adverse effects [2]. Phototherapy, which includes narrowband ultraviolet B (NB-UVB) and PUVA therapy, is also an option for patients with moderate to severe psoriasis [3].

Biological agents have revolutionized psoriasis treatment, especially in cases of moderate to severe disease. These include TNF inhibitors, IL-17, and IL-23 inhibitors, which have shown to significantly improve patients' quality of life by providing more effective control of symptoms [4]. However, their high cost and the possibility of immunological adverse effects are challenges that must be considered in clinical practice [5].

Conclusions

The management of psoriasis is a constantly evolving field, with significant advances in the development of more effective and personalized treatments. The combination of topical, systemic, and biological therapies offers a comprehensive approach to treating this complex disease. Ongoing research and collaboration between clinicians and researchers are essential to optimize treatment and improve the quality of life for patients with psoriasis.

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Created 5/1/2025