Genital Herpes Treatment: Acyclovir, Valacyclovir, and Chronic Suppression Strategies

Genital herpes is one of the most common sexually transmitted infections worldwide, caused by the herpes simplex virus (HSV), primarily types 1 and 2. This infection is characterized by its chronic nature, with episodes of reactivation that can be symptomatic or asymptomatic. The prevalence of this disease and its impact on patients' quality of life underscore the importance of adequate and effective management.

Antiviral Treatment and Outbreak Prevention

The treatment of genital herpes focuses on the use of antivirals such as acyclovir, valacyclovir, and famciclovir. These medications are effective in reducing the duration and severity of outbreaks, as well as decreasing the frequency of recurrences. Evidence suggests that chronic suppression therapy with these antivirals can be particularly beneficial for patients with frequent or severe episodes, improving their quality of life and reducing the risk of transmission to sexual partners.

Daily use of suppressive antiviral therapy has been shown to significantly reduce both clinical and subclinical reactivation of the virus, which is crucial for preventing asymptomatic transmission. Additionally, sexual counseling is an integral part of managing genital herpes, as educating patients about the nature of the disease and preventive measures can help reduce the spread of the virus.

Conclusions

Despite advances in the treatment of genital herpes, the infection remains a challenge due to its chronic nature and the lack of a definitive cure. However, proper management with antivirals and prevention strategies can significantly improve patients' quality of life and reduce transmission. Ongoing research into vaccines and new therapies offers hope for the future in the fight against this prevalent infection.

Referencias

• [1] Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients.
• [2] HSV shedding.
• [3] Genital Herpes: A Review.
• [4] An Insight into Current Treatment Strategies, Their Limitations, and Ongoing Developments in Vaccine Technologies against Herpes Simplex Infections.

Created 6/1/2025