Endometrial Cancer: Early Warning Signs of Abnormal Uterine Bleeding and Biopsy Techniques
Endometrial cancer is one of the most common gynecological neoplasms, and its early detection is crucial for improving clinical outcomes. Abnormal uterine bleeding (AUB) is often the first warning sign, especially in postmenopausal women. Proper identification and evaluation of this symptom can facilitate early diagnosis and timely treatment.
Diving Deeper into the Topic
AUB can indicate various endometrial pathologies, including hyperplasia and endometrial cancer. A recent study has developed predictive models to identify endometrial hyperplasia and cancer in patients with recurrent AUB, highlighting risk factors such as advanced age, nulliparity, and a history of endometrial polyps [1]. The endometrial biopsy is an essential diagnostic tool in these cases and is especially recommended for women with elevated risk factors [2].
Transvaginal ultrasound is another non-invasive technique used to assess endometrial thickness and detect abnormalities. Studies have shown that an endometrial thickness greater than 8 mm in perimenopausal women with AUB is associated with a higher risk of hyperplasia or cancer [3]. Additionally, hysteroscopy with directed biopsy is the method with the highest diagnostic accuracy and cost-effectiveness for detecting endometrial malignancies [4].
Conclusions
Early detection of endometrial cancer through the evaluation of AUB and the use of appropriate biopsy techniques is fundamental for improving patient prognosis. The combination of imaging methods such as transvaginal ultrasound and diagnostic procedures like endometrial biopsy can provide a comprehensive and accurate assessment. It is imperative that healthcare professionals maintain a high index of suspicion and utilize these tools effectively to ensure early diagnosis and appropriate treatment.
Referencias
- [1] Predicting Endometrial Hyperplasia and Endometrial Cancer on Recurrent Abnormal Uterine Bleeding.
- [2] Endometrial biopsy: Indications, techniques and recommendations. An evidence-based guideline for clinical practice.
- [3] Endometrial Thickness Measurement as Predictor of Endometrial Hyperplasia and Cancer in Perimenopausal Uterine Bleeding: Cross-Sectional Study.
- [4] Comparing endometrial biopsy results with hysteroscopic pathology in women presenting with abnormal and postmenopausal uterine bleeding.
Created 13/1/2025